PUBLICATION
Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development
- Authors
- Duan, Z., Wang, J., Zhang, H., Wang, Y., Chen, Y., Cong, J., Gong, Z., Sun, H., Wang, L.
- ID
- ZDB-PUB-230709-39
- Date
- 2023
- Source
- Journal of hazardous materials 458: 131679131679 (Journal)
- Registered Authors
- Gong, Zhiyuan
- Keywords
- Cardiovascular disease, Global warming, Multi-omic analysis, Nanoplastics, Oxidative phosphorylation
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian
- Larva
- Microplastics/metabolism
- Myocardium/metabolism
- Temperature
- Water Pollutants, Chemical*/toxicity
- Zebrafish*/metabolism
- PubMed
- 37421853 Full text @ J. Hazard. Mater.
Citation
Duan, Z., Wang, J., Zhang, H., Wang, Y., Chen, Y., Cong, J., Gong, Z., Sun, H., Wang, L. (2023) Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development. Journal of hazardous materials. 458:131679131679.
Abstract
To highlight the key role of global warming on the toxicity of contaminants, the cardiovascular toxicity of nanoparticles (NPs) was estimated in developing zebrafish (Danio rerio) at different exposure temperatures, and the toxicity mechanisms were explored via multi-omic analyses. Polystyrene NPs (50 nm) at 0.1 mg·L-1 entered zebrafish embryos at 24 h post-fertilization and caused cardiovascular toxicity in the developing zebrafish at 27 ℃. This was explained by the down-regulation of the branched-chain amino acid and insulin signaling pathways owing to induced oxidative stress. Elevated exposure temperatures promoted the accumulation of NPs in developing zebrafish, increased the levels of oxidative stress and enhanced the oxidative phosphorylation rate in mitochondria, thus resulting in an additive effect on the mortality of zebrafish larvae. Notably, elevated exposure temperatures reduced the cardiovascular toxicity of NPs, as the effective concentration of NPs for inhibiting embryonic heartbeat rate increased from 0.1 mg·L-1 at 27 ℃ to 1.0 mg·L-1 at 30 ℃. Experiments of transgenic zebrafish Tg(myl7:GFP) and multi-omic analyses revealed that elevated temperatures enhanced the myocardial contractility of larvae, thus reducing the cardiovascular toxicity of NPs. However, the health risks of enhanced myocardial contraction caused by NP exposure at elevated temperatures requires further consideration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping