PUBLICATION
Zebrafish: A Relevant Genetic Model for Human Primary Immunodeficiency (PID) Disorders?
- Authors
- Basheer, F., Sertori, R., Liongue, C., Ward, A.C.
- ID
- ZDB-PUB-230414-51
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(7): (Review)
- Registered Authors
- Liongue, Clifford, Ward, Alister C.
- Keywords
- immunity, immunodeficiency, zebrafish
- MeSH Terms
-
- Animals
- Female
- Humans
- Immunologic Deficiency Syndromes*/genetics
- Immunologic Deficiency Syndromes*/therapy
- Models, Genetic
- Pelvic Inflammatory Disease*
- Primary Immunodeficiency Diseases*/genetics
- Severe Combined Immunodeficiency*/genetics
- Zebrafish/genetics
- PubMed
- 37047441 Full text @ Int. J. Mol. Sci.
Citation
Basheer, F., Sertori, R., Liongue, C., Ward, A.C. (2023) Zebrafish: A Relevant Genetic Model for Human Primary Immunodeficiency (PID) Disorders?. International Journal of Molecular Sciences. 24(7):.
Abstract
Primary immunodeficiency (PID) disorders, also commonly referred to as inborn errors of immunity, are a heterogenous group of human genetic diseases characterized by defects in immune cell development and/or function. Since these disorders are generally uncommon and occur on a variable background profile of potential genetic and environmental modifiers, animal models are critical to provide mechanistic insights as well as to create platforms to underpin therapeutic development. This review aims to review the relevance of zebrafish as an alternative genetic model for PIDs. It provides an overview of the conservation of the zebrafish immune system and details specific examples of zebrafish models for a multitude of specific human PIDs across a range of distinct categories, including severe combined immunodeficiency (SCID), combined immunodeficiency (CID), multi-system immunodeficiency, autoinflammatory disorders, neutropenia and defects in leucocyte mobility and respiratory burst. It also describes some of the diverse applications of these models, particularly in the fields of microbiology, immunology, regenerative biology and oncology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping