PUBLICATION
Novel regulatory mechanisms underlying angiogenesis during wound healing revealed by fluorescence-based live-imaging in zebrafish
- Authors
- Yuge, S., Ishii, T., Noishiki, C., Fukuhara, S.
- ID
- ZDB-PUB-230318-41
- Date
- 2023
- Source
- Journal of biochemistry 174(1): 5-12 (Review)
- Registered Authors
- Fukuhara, Shigetomo, Ishii, Tomohiro, Yuge, Shinya
- Keywords
- TOCA family of F-BAR proteins, endothelial cells, pericytes, wound angiogenesis, zebrafish
- MeSH Terms
-
- Animals
- Endothelial Cells*
- Fluorescence
- Neovascularization, Physiologic/physiology
- Wound Healing/physiology
- Zebrafish*
- PubMed
- 36931281 Full text @ J. Biochem.
Citation
Yuge, S., Ishii, T., Noishiki, C., Fukuhara, S. (2023) Novel regulatory mechanisms underlying angiogenesis during wound healing revealed by fluorescence-based live-imaging in zebrafish. Journal of biochemistry. 174(1):5-12.
Abstract
Angiogenesis is a dynamic morphogenetic process that refers to the growth of new blood vessels from the pre-existing vessels and is critical for tissue repair during wound healing. In adult normal tissues, quiescent endothelial cells and pericytes maintain vascular integrity, whereas angiogenesis is immediately induced upon tissue injury, thereby forming neovascular networks to maintain homeostasis. However, impaired angiogenesis results in development of chronic and non-healing wounds in various diseases such as diabetes and peripheral artery diseases. Zebrafish are a vertebrate model organism widely used for studying many medical and life science fields. Indeed, the molecular and cellular mechanisms underlying regulation of wound angiogenesis have recently been studied by performing fluorescence-based live-imaging of adult zebrafish. In this review, we describe how endothelial cells and pericytes establish neovascular networks during wound angiogenesis and also introduce a novel role of blood flow-driven intraluminal pressure in regulating angiogenesis during wound healing.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping