PUBLICATION
Zebrafish cutaneous injury models reveal Langerhans cells engulf axonal debris in adult epidermis
- Authors
- Peterman, E., Quitevis, E.J.A., Black, E.C., Horton, E.C., Aelmore, R.L., White, E., Sagasti, A., Rasmussen, J.P.
- ID
- ZDB-PUB-230307-40
- Date
- 2023
- Source
- Disease models & mechanisms 16(4): (Journal)
- Registered Authors
- Rasmussen, Jeff, Sagasti, Alvaro
- Keywords
- Homeostasis, Somatosensory axons, Tissue repair, Wallerian degeneration, Wound healing, Zebrafish
- MeSH Terms
-
- Animals
- Axons/pathology
- Epidermis/pathology
- Langerhans Cells/pathology
- Wallerian Degeneration*/pathology
- Zebrafish*
- PubMed
- 36876992 Full text @ Dis. Model. Mech.
Citation
Peterman, E., Quitevis, E.J.A., Black, E.C., Horton, E.C., Aelmore, R.L., White, E., Sagasti, A., Rasmussen, J.P. (2023) Zebrafish cutaneous injury models reveal Langerhans cells engulf axonal debris in adult epidermis. Disease models & mechanisms. 16(4):.
Abstract
Somatosensory neurons extend enormous peripheral axons to the skin, where they detect diverse environmental stimuli. Somatosensory peripheral axons are easily damaged due to their small caliber and superficial location. Axonal damage results in Wallerian degeneration, creating vast quantities of cellular debris that phagocytes must remove to maintain organ homeostasis. The cellular mechanisms that ensure efficient clearance of axon debris from stratified adult skin are unknown. Here, we establish zebrafish scales as a tractable model to study axon degeneration in the adult epidermis. Using this system, we demonstrate that skin-resident immune cells known as Langerhans cells engulf the majority of axon debris. In contrast to immature skin, adult keratinocytes do not significantly contribute to debris removal, even in animals lacking Langerhans cells. Our study establishes a powerful new model for studying Wallerian degeneration and identifies a new function for Langerhans cells in maintenance of adult skin homeostasis following injury. These findings have important implications for pathologies that trigger somatosensory axon degeneration.
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
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