PUBLICATION
From worms to humans: Understanding intestinal lipid metabolism via model organisms
- Authors
- Kozan, D.W., Derrick, J.T., Ludington, W.B., Farber, S.A.
- ID
- ZDB-PUB-230205-21
- Date
- 2023
- Source
- Biochimica et biophysica acta. Molecular and cell biology of lipids 1868(4): 159290 (Review)
- Registered Authors
- Farber, Steven, Kozan, Darby
- Keywords
- Apolipoprotein B, Chylomicron, Drosophila, Fatty acid, Intestine, Lipids, Metabolic disease, Model organism, Zebrafish
- MeSH Terms
-
- Animals
- Diabetes Mellitus, Type 2*
- Dietary Fats/metabolism
- Humans
- Intestinal Absorption
- Intestines
- Lipid Metabolism*/physiology
- PubMed
- 36738984 Full text @ BBA Molecular and Cell Biology of Lipids
Citation
Kozan, D.W., Derrick, J.T., Ludington, W.B., Farber, S.A. (2023) From worms to humans: Understanding intestinal lipid metabolism via model organisms. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159290.
Abstract
The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping