PUBLICATION
Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo
- Authors
- Sullivan, M.P., Adams, M., Riisom, M., Herbert, C.D., Tong, K.K.H., Astin, J.W., Jamieson, S.M.F., Hanif, M., Goldstone, D.C., Hartinger, C.G.
- ID
- ZDB-PUB-230114-3
- Date
- 2023
- Source
- Dalton transactions (Cambridge, England : 2003) 52(5): 1388-1392 (Journal)
- Registered Authors
- Astin, Jonathan
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents*/pharmacology
- Cell Line, Tumor
- DNA
- Ligands
- Platinum*
- Zebrafish
- PubMed
- 36637059 Full text @ Dalton Trans.
Citation
Sullivan, M.P., Adams, M., Riisom, M., Herbert, C.D., Tong, K.K.H., Astin, J.W., Jamieson, S.M.F., Hanif, M., Goldstone, D.C., Hartinger, C.G. (2023) Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo. Dalton transactions (Cambridge, England : 2003). 52(5):1388-1392.
Abstract
Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cisplatin. DNA interaction studies support a mode of action related to intercalation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping