PUBLICATION
Cosmeceutical Effects of Ishige okamurae Celluclast Extract
- Authors
- Yang, F., Hyun, J., Nagahawatta, D.P., Kim, Y.M., Heo, M.S., Jeon, Y.J.
- ID
- ZDB-PUB-221224-13
- Date
- 2022
- Source
- Antioxidants (Basel, Switzerland) 11(12): (Journal)
- Registered Authors
- Jeon, You-Jin
- Keywords
- Celluclast, Ishige okamurae, anti-inflammatory activity, antioxidant activity, cosmeceutical effect, photoprotective effect, sulfated polysaccharides
- MeSH Terms
- none
- PubMed
- 36552650 Full text @ Antioxidants (Basel)
Citation
Yang, F., Hyun, J., Nagahawatta, D.P., Kim, Y.M., Heo, M.S., Jeon, Y.J. (2022) Cosmeceutical Effects of Ishige okamurae Celluclast Extract. Antioxidants (Basel, Switzerland). 11(12):.
Abstract
Sulfated polysaccharides extracted from brown algae are unique algal polysaccharides and potential ingredients in the cosmeceutical, functional food, and pharmaceutical industries. Therefore, the present study evaluated the cosmeceutical effects, including antioxidant, anti-wrinkle, anti-inflammation, and photoprotective activities, of Ishige okamurae Celluclast extract (IOC). The IOC was abundant in sulfated polysaccharides (48.47%), polysaccharides (44.33%), and fucose (43.50%). Moreover, the IOC effectively scavenged free radicals, and its anti-inflammatory properties were confirmed in lipopolysaccharide-induced RAW 264.7 macrophages; therefore, the IOC may produce auxiliary effects by inhibiting reactive oxygen species (ROS). In vitro (Vero cells) and in vivo (zebrafish) studies further confirmed that the IOC produced a protective effect against hydrogen-peroxide-induced oxidative stress in a dose-dependent manner. In addition, the IOC suppressed intracellular ROS and apoptosis and enhanced HO-1 and SOD-1 expression through transcriptional activation of Nrf2 and downregulation of Keap1 in HaCaT cells. Furthermore, the IOC exhibited a potent protective effect against ultraviolet-B-induced skin damage and photoaging. In conclusion, the IOC possesses antioxidant, anti-inflammatory, and photoprotective activities, and can, therefore, be utilized in the cosmeceutical and functional food industries.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping