PUBLICATION
Transparent Anti-SARS COV-2 Film from Copper(I) Oxide Incorporated in Zeolite Nanoparticles
- Authors
- Jampa, S., Ratanatawanate, C., Pimtong, W., Aueviriyavit, S., Chantho, V., Sillapaprayoon, S., Kunyanee, C., Warin, C., Gamonchuang, J., Kumnorkaew, P.
- ID
- ZDB-PUB-221115-2
- Date
- 2022
- Source
- ACS applied materials & interfaces 14(46): 52334-52346 (Journal)
- Registered Authors
- Pimtong, Wittaya
- Keywords
- antibacterial activity, antiviral activity, cuprous oxide, nanoparticles, zeolite
- MeSH Terms
-
- Animals
- Anti-Bacterial Agents/chemistry
- Antiviral Agents/pharmacology
- COVID-19*
- Copper/chemistry
- Copper/pharmacology
- Gram-Positive Bacteria
- Humans
- Microbial Sensitivity Tests
- Nanoparticles*/chemistry
- Oxides
- SARS-CoV-2
- Swine
- Zebrafish
- Zeolites*/chemistry
- PubMed
- 36352778 Full text @ ACS Appl. Mater. Interfaces
Citation
Jampa, S., Ratanatawanate, C., Pimtong, W., Aueviriyavit, S., Chantho, V., Sillapaprayoon, S., Kunyanee, C., Warin, C., Gamonchuang, J., Kumnorkaew, P. (2022) Transparent Anti-SARS COV-2 Film from Copper(I) Oxide Incorporated in Zeolite Nanoparticles. ACS applied materials & interfaces. 14(46):52334-52346.
Abstract
The high antibacterial and antiviral performance of synthesized copper(I) oxide (Cu2O) incorporated in zeolite nanoparticles (Cu-Z) was determined. Various Cu contents (1-9 wt %) in solutions were loaded in the zeolite matrix under neutral conditions at room temperature. All synthesized Cu-Z nanoparticles showed high selectivity of the cuprous oxide, as confirmed by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis. An advantage of the prepared Cu-Z over the pristine Cu2O nanoparticles was its high thermal stability. The 7 and 9 wt % Cu contents (07Cu-Z and 09Cu-Z) exhibited the best activities to deactivate Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. The film coated with 07Cu-Z nanoparticles also had high antiviral activities against porcine coronavirus (porcine epidemic diarrhea virus, PEDV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Specifically, the 07Cu-Z-coated film could reduce 99.93% of PEDV and 99.94% of SARS-CoV-2 viruses in 5 min of contact time, which were higher efficacies and faster than those of any previously reported works. The anti-SARS-CoV-2 virus film was coated on a low-cost PET or PVC film. A very small amount of cuprous oxide in zeolite was used to fabricate the antivirus film; therefore, the film was more transparent (79.4% transparency) than the cuprous oxide film or other commercial products. The toxicity of 07Cu-Z nanoparticles was determined by a toxicity test on zebrafish embryo and a skin irritation test to reconstruct a human epidermis (RhE) model. It was found that the impact on the aquatic environment and human skin was lower than that of the pristine Cu2O.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping