PUBLICATION
Microarray expression profiling of fndc3a zebrafish mutants
- Authors
- Liedtke, D., Klopocki, E.
- ID
- ZDB-PUB-221019-2
- Date
- 2022
- Source
- microPublication. Biology 2022: (Journal)
- Registered Authors
- Klopocki, Eva, Liedtke, Daniel
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 36254247 Full text @ MicroPubl Biol
Citation
Liedtke, D., Klopocki, E. (2022) Microarray expression profiling of fndc3a zebrafish mutants. microPublication. Biology. 2022:.
Abstract
The group of Fibronectin type III domain-containing (FNDC; InterPro IPR003961) protein super family splits into a large number of gene-orthologues and mediates a variety of cellular functions during development and disease. They act as anti-inflammatory factors, are linked to cell-cell-interactions, regulate cell signaling and are associated with different cancer types, like cervical and colorectal. One member of this gene family is FNDC3A , which influences different developmental processes in vertebrates, like Sertoli cell/spermatid adhesion in mice testis, bone traits in chicken, and fin development in zebrafish. To identify downstream molecular processes during vertebrate development we investigated gene expression profiles in the previously established fndc3a zebrafish mutants via microarray analyses on 22 hpf embryos (26-somite stage). Our analyses imply distinct transcriptional profiles between genotype groups and hint to altered cell binding and catalytic activity in fndc3a mutants.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping