PUBLICATION
Metzincin Metalloproteases in PGC Migration and Gonadal Sex Conversion
- Authors
- Carver, J.J., Zhu, Y.
- ID
- ZDB-PUB-221004-18
- Date
- 2022
- Source
- General and comparative endocrinology 330: 114137 (Review)
- Registered Authors
- Zhu, Yong
- Keywords
- ADAMTSs, ADAMs, Folliculogenesis, Gonadal Differentiation, MMPs, Metalloproteases, Oogenesis, Ovarian Development, PGC, Sex Conversion, Sex Determination, Sex Reversal, Spermatogenesis, Steroidogenesis, Zebrafish
- MeSH Terms
-
- Animals
- Disintegrins*
- Germ Cells
- Gonads
- Metalloproteases
- Sex Differentiation
- Zebrafish*
- PubMed
- 36191636 Full text @ Gen. Comp. Endocrinol.
Citation
Carver, J.J., Zhu, Y. (2022) Metzincin Metalloproteases in PGC Migration and Gonadal Sex Conversion. General and comparative endocrinology. 330:114137.
Abstract
Development of a functional gonad includes migration of primordial germ cells (PGCs), differentiations of somatic and germ cells, formation of primary follicles or spermatogenic cysts with somatic gonadal cells, development and maturation of gametes, and subsequent releasing of mature germ cells. These processes require extensive cellular and tissue remodeling, as well as broad alterations of the surrounding extracellular matrix (ECM). Metalloproteases, including MMPs (matrix metalloproteases), ADAMs (a disintegrin and metalloproteinases), and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs), are suggested to have critical roles in the remodeling of the ECM during gonad development. However, few research articles and reviews are available on the functions and mechanisms of metalloproteases in remodeling gonadal ECM, gonadal development, or gonadal differentiation. Moreover, most studies focused on the roles of transcription and growth factors in early gonad development and primary sex determination, leaving a significant knowledge gap on how differentially expressed metalloproteases exert effects on the ECM, cell migration, development, and survival of germ cells during the development and differentiation of ovaries or testes. We will review gonad development with focus on the evidence of metalloprotease involvements, and with an emphasis on zebrafish as a model for studying gonadal sex differentiation and metalloprotease functions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping