PUBLICATION
Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology
- Authors
- MacRae, C.A., Peterson, R.T.
- ID
- ZDB-PUB-220925-1
- Date
- 2022
- Source
- Annual Review of Pharmacology and Toxicology 63: 43-64 (Review)
- Registered Authors
- MacRae, Calum A., Peterson, Randall
- Keywords
- none
- MeSH Terms
-
- Animals
- Humans
- Network Pharmacology
- Toxicology*
- Zebrafish*/genetics
- PubMed
- 36151053 Full text @ Annu. Rev. Pharmacol. Toxicol.
Citation
MacRae, C.A., Peterson, R.T. (2022) Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology. Annual Review of Pharmacology and Toxicology. 63:43-64.
Abstract
Pharmacology and toxicology are part of a much broader effort to understand the relationship between chemistry and biology. While biomedicine has necessarily focused on specific cases, typically of direct human relevance, there are real advantages in pursuing more systematic approaches to characterizing how health and disease are influenced by small molecules and other interventions. In this context, the zebrafish is now established as the representative screenable vertebrate and, through ongoing advances in the available scale of genome editing and automated phenotyping, is beginning to address systems-level solutions to some biomedical problems. The addition of broader efforts to integrate information content across preclinical model organisms and the incorporation of rigorous analytics, including closed-loop deep learning, will facilitate efforts to create systems pharmacology and toxicology with the ability to continuously optimize chemical biological interactions around societal needs. In this review, we outline progress toward this goal. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 63 is January 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping