PUBLICATION
The antagonistic activity of Padina arborescens extracts on mPRα
- Authors
- Acharjee, M., Ali, M.H., Jyoti, M.M.S., Rezanujjaman, M., Hassan, M.M., Rana, M.R., Hossain, M.F., Kodani, S., Tokumoto, T.
- ID
- ZDB-PUB-220907-45
- Date
- 2022
- Source
- Natural Product Research 37(11): 1872-1876 (Journal)
- Registered Authors
- Tokumoto, Toshinobu
- Keywords
- Marine algae, Padina arborescens, membrane progesterone receptor, steroid binding assay
- MeSH Terms
-
- Animals
- Female
- Oocytes/metabolism
- Pharmaceutical Preparations
- Progesterone*/metabolism
- Receptors, Progesterone*/metabolism
- Zebrafish/metabolism
- PubMed
- 36067477 Full text @ Nat. Prod. Res.
Citation
Acharjee, M., Ali, M.H., Jyoti, M.M.S., Rezanujjaman, M., Hassan, M.M., Rana, M.R., Hossain, M.F., Kodani, S., Tokumoto, T. (2022) The antagonistic activity of Padina arborescens extracts on mPRα. Natural Product Research. 37(11):1872-1876.
Abstract
The current study attempted to evaluate the antagonistic activity of compounds isolated and purified from the marine algae Padina arborescens during cultivation. The compounds were collected on a filter, concentrated on ODS columns and separated by HPLC. Two peaks that showed competitive progesterone binding activity with membrane progesterone receptor α (mPRα) were purified. Their physiological activity was further uncovered by in vitro and in vivo oocyte maturation and ovulation-inducing assays using zebrafish. The compounds inhibited the induction of oocyte maturation and ovulation. Moreover, the results showed that the compounds have antagonistic activity against mPRα. The purified compounds with antagonistic activity against mPRα would be considered as new pharmaceutical candidate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping