PUBLICATION
Identification, conservation, and expression of tiered pharmacogenes in zebrafish
- Authors
- Demery-Poulos, C., Chambers, J.M.
- ID
- ZDB-PUB-220831-20
- Date
- 2022
- Source
- PLoS One 17: e0273582 (Journal)
- Registered Authors
- Chambers, Joseph, Demery, Catherine
- Keywords
- none
- MeSH Terms
-
- Animals
- Drug-Related Side Effects and Adverse Reactions*
- Humans
- Models, Animal
- Pharmacogenetics
- Precision Medicine
- Zebrafish*/genetics
- PubMed
- 36040978 Full text @ PLoS One
Citation
Demery-Poulos, C., Chambers, J.M. (2022) Identification, conservation, and expression of tiered pharmacogenes in zebrafish. PLoS One. 17:e0273582.
Abstract
The number of adverse drug events in the United States is critically high, with annual rates exceeding 1 million cases over the last nine years. One cause of adverse drug events is the underlying genetic variation that can alter drug responses. Pharmacogenomics is a growing field that seeks to better understand the relationship between a patient's genetics and drug efficacy. Currently, pharmacogenomics relies largely on human trials, as there is not a well-developed animal model for studying preventative measures and alternative treatments. Here, we analyzed pharmacogene expression at two developmental time points in zebrafish to demonstrate the potential of using this model organism for high-throughput pharmacogenomics research. We found that 76% of tiered human pharmacogenes have a zebrafish ortholog, and of these, many have highly conserved amino acid sequences. Additional gene ontology analysis was used to classify pharmacogenes and identify candidate pathways for future modeling in zebrafish. As precision medicine burgeons, adopting a high-throughput in vivo model such as the zebrafish could greatly increase our understanding of the molecular pathology underlying adverse drug events.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping