PUBLICATION
A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury
- Authors
- Liu, C., Zhou, L., Zheng, Y., Man, H., Ye, Z., Zhang, X., Xie, L., Xiao, Y.
- ID
- ZDB-PUB-220824-15
- Date
- 2022
- Source
- Chemical communications (Cambridge, England) 58(72): 10052-10055 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Chemical and Drug Induced Liver Injury, Chronic*
- Ethanol/toxicity
- Fluorescent Dyes*
- Microscopy, Fluorescence/methods
- Viscosity
- Zebrafish
- PubMed
- 35993173 Full text @ Chem. Commun. (Camb.)
Citation
Liu, C., Zhou, L., Zheng, Y., Man, H., Ye, Z., Zhang, X., Xie, L., Xiao, Y. (2022) A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury. Chemical communications (Cambridge, England). 58(72):10052-10055.
Abstract
We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping