PUBLICATION
Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice
- Authors
- Li, Z., Wu, N., Wang, J., Yue, Y., Geng, L., Zhang, Q.
- ID
- ZDB-PUB-220717-8
- Date
- 2022
- Source
- International journal of biological macromolecules 217: 345-355 (Journal)
- Registered Authors
- Keywords
- Angiogenesis, Diabetes, Fucoidan
- MeSH Terms
-
- Animals
- Antineoplastic Agents*/therapeutic use
- Diabetes Mellitus, Type 2*/complications
- Diabetes Mellitus, Type 2*/drug therapy
- Human Umbilical Vein Endothelial Cells
- Humans
- Mice
- Molecular Weight
- Neovascularization, Pathologic/drug therapy
- Polysaccharides/pharmacology
- Polysaccharides/therapeutic use
- Zebrafish
- PubMed
- 35841956 Full text @ Int. J. Biol. Macromol.
Citation
Li, Z., Wu, N., Wang, J., Yue, Y., Geng, L., Zhang, Q. (2022) Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice. International journal of biological macromolecules. 217:345-355.
Abstract
Diabetes leading to brain glucose metabolism disorders and cerebrovascular complications. Fucoidan is a kind of sulfated polysaccharides which found in brown algae, has multiply bioactivities and considered to be a promising therapeutic agent. Despite the increasing amount of evidence suggesting the diabetes protective role of fucoidans, the effect of fucoidan on brain abnormalities in type 2 diabetes mellitus patients remains unclear. In this study a low molecular weight fucoidan (LMWF) was obtained from Saccharina japonica and its effect on the cerebrovascular damage in db/db mice was investigated. Results were shown after LMWF treatment, the degree of cerebrovascular damage, the number of apoptotic neuronal cells and the inflammation were all decreased in db/db mice. Moreover, LMWF could up-regulates CD34 and VEGFA expression in db/db mice brain, and the subintestinal vessel angiogenesis in zebrafish was also promoted by LMWF. Moreover, the lumen formation of HUVEC endothelial cells was rescued by LMWF which was destroyed in high glucose treated endothelial cells. Further study found, LMWF alleviates vascular injury by up-regulating the expression level of phosphorylated PI3K and phosphorylated AKT. Our study indicates that LMWF has the potential to develop a cerebrovascular protection agent for type 2 diabetes patients.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping