PUBLICATION
Drug-Eluting Rubber Bands for Tissue Ligation
- Authors
- Feiner, R., Johns, E., Antman-Passig, M., Irie, T., Berisha, N., Oved, H., Khan, D., Witek, L., White, R.M., Heller, D.A.
- ID
- ZDB-PUB-220608-5
- Date
- 2022
- Source
- ACS applied materials & interfaces 14(24): 27675-27685 (Journal)
- Registered Authors
- White, Richard M.
- Keywords
- controlled release, drug delivery, drug release, elastomer, hemorrhoids, pain management, rubber
- MeSH Terms
-
- Animals
- Humans
- Ligation/adverse effects
- Ligation/methods
- Pain/etiology
- Quality of Life*
- Treatment Outcome
- Zebrafish*
- PubMed
- 35670525 Full text @ ACS Appl. Mater. Interfaces
Citation
Feiner, R., Johns, E., Antman-Passig, M., Irie, T., Berisha, N., Oved, H., Khan, D., Witek, L., White, R.M., Heller, D.A. (2022) Drug-Eluting Rubber Bands for Tissue Ligation. ACS applied materials & interfaces. 14(24):27675-27685.
Abstract
Rubber band ligation is a commonly used method for the removal of tissue abnormalities. Most often, rubber band ligation is performed to remove internal hemorrhoids unresponsive to first line treatments to avoid surgery. While the procedure is considered safe, patients experience mild to significant pain and discomfort until the tissue sloughs off. As patients often require multiple bandings and sessions, reducing these side effects can have a considerable effect on patient adherence and quality of life. To reduce pain and discomfort, we developed drug-eluting rubber bands for ligation procedures. We investigated the potential for a band to elute anesthetics and drug combinations to durably manage pain for a period of up to 5 days while exhibiting similar mechanical properties to conventional rubber bands. We show that the rubber bands retain their mechanical properties despite significant drug loading. Lidocaine, released from the bands, successfully altered the calcium dynamics of cardiomyocytes in vitro and modulated heart rate in zebrafish embryos, while the bands exhibited lower cytotoxicity than conventional bands. Ex vivo studies demonstrated substantial local drug release in enteric tissues. These latex-free bands exhibited sufficient mechanical and drug-eluting properties to serve both ligation and local analgesic functions, potentially enabling pain reduction for multiple indications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping