PUBLICATION
Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/β-Catenin Signaling Pathway
- Authors
- Sun, C., Liu, Q., Shah, M., Che, Q., Zhang, G., Zhu, T., Zhou, J., Rong, X., Li, D.
- ID
- ZDB-PUB-220527-9
- Date
- 2022
- Source
- Organic letters 24(22): 3993-3997 (Journal)
- Registered Authors
- Rong, Xiaozhi, Zhou, Jianfeng
- Keywords
- none
- MeSH Terms
-
- Animals
- Antarctic Regions
- Mammals/metabolism
- Talaromyces*/metabolism
- Wnt Signaling Pathway*
- Zebrafish
- beta Catenin/metabolism
- PubMed
- 35616425 Full text @ Org. Lett.
Citation
Sun, C., Liu, Q., Shah, M., Che, Q., Zhang, G., Zhu, T., Zhou, J., Rong, X., Li, D. (2022) Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/β-Catenin Signaling Pathway. Organic letters. 24(22):3993-3997.
Abstract
The Wnt/β-catenin signaling pathway is an evolutionarily conserved signaling cascade involved in a broad range of biological roles. Dysregulation of the Wnt/β-catenin pathway is implicated in congenital malformations and various kinds of cancers. We discovered a novel Wnt/β-catenin inhibitor, talaverrucin A (1), featuring an unprecedented 6/6/6/5/5/5/6 fused ring system, from an Antarctica sponge-derived fungus Talaromyces sp. HDN151403. Talaverrucin A exhibits inhibitory activity on the Wnt/β-catenin pathway in both zebrafish embryos in vivo and cultured mammalian cells in vitro, providing a naturally inspired small molecule therapeutic lead to target the Wnt/β-catenin pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping