PUBLICATION

Developmental independence of median fins from the larval fin fold revises their evolutionary origin

Authors
Miyamoto, K., Kawakami, K., Tamura, K., Abe, G.
ID
ZDB-PUB-220509-2
Date
2022
Source
Scientific Reports   12: 7521 (Journal)
Registered Authors
Abe, Gembu, Kawakami, Koichi
Keywords
none
MeSH Terms
  • Animal Fins*/anatomy & histology
  • Animals
  • Larva
  • Phylogeny
  • Zebrafish*
PubMed
35525860 Full text @ Sci. Rep.
Abstract
The median fins of modern fish that show discrete forms (dorsal, anal, and caudal fins) are derived from a continuous fold-like structure, both in ontogeny and phylogeny. The median fin fold (MFF) hypothesis assumes that the median fins evolved by reducing some positions in the continuous fin fold of basal chordates, based on the classical morphological observation of developmental reduction in the larval fin folds of living fish. However, the developmental processes of median fins are still unclear at the cellular and molecular levels. Here, we describe the transition from the larval fin fold into the median fins in zebrafish at the cellular and molecular developmental level. We demonstrate that reduction does not play a role in the emergence of the dorsal fin primordium. Instead, the reduction occurs along with body growth after primordium formation, rather than through actively scrapping the non-fin forming region by inducing cell death. We also report that the emergence of specific mesenchymal cells and their proliferation promote dorsal fin primordium formation. Based on these results, we propose a revised hypothesis for median fin evolution in which the acquisition of de novo developmental mechanisms is a crucial evolutionary component of the discrete forms of median fins.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes