PUBLICATION

The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish

Authors
Anneser, L., Gemmer, A., Eilers, T., Alcantara, I.C., Loos, A.Y., Ryu, S., Schuman, E.M.
ID
ZDB-PUB-220305-8
Date
2022
Source
iScience   25: 103868 (Journal)
Registered Authors
Anneser, Lukas, Loos, Anett-Yvonn, Ryu, Soojin, Schuman, Erin
Keywords
Behavioral neuroscience, Biological sciences, Molecular neuroscience
MeSH Terms
none
PubMed
35243231 Full text @ iScience
Abstract
Behavior is context-dependent and often modulated by an animal's internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is regulated by the presence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social behavior paradigms. Here, we show that the propensity to react to sudden stimuli with an escape response was increased in pth2-/- zebrafish, consistent with an elevated anxiety level. While overall social preference for conspecifics was maintained in pth2-/- fish until the early juvenile stage, we found that both social preference and shoaling were altered later in development. The data presented suggest that the neuropeptide Pth2 modulates several conserved behaviors and may thus enable the animal to react appropriately in different social contexts.
Genes / Markers
Figures
Figure Gallery (4 images)
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
sa23129
    		Point Mutation
    1 - 1 of 1
    Show
    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    Fish
    pth2sa23129/sa23129
    WT
    1 - 2 of 2
    Show
    Antibodies
    Name Type Antigen Genes Isotypes Host Organism
    Ab1-pth2polyclonalGuinea pig
    1 - 1 of 1
    Show
    Orthology
    No data available
    Engineered Foreign Genes
    No data available
    Mapping
    No data available
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    Citation
    Anneser, L., Gemmer, A., Eilers, T., Alcantara, I.C., Loos, A.Y., Ryu, S., Schuman, E.M. (2022) The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish. iScience. 25:103868.