PUBLICATION
A rational study of the influence of Mn2+-insertion in Prussian blue nanoparticles on their photothermal properties
- Authors
- Cahu, M., Ali, L.M.A., Sene, S., Long, J., Camerel, F., Ciancone, M., Salles, F., Chopineau, J., Devoisselle, J.M., Felix, G., Cubedo, N., Rossel, M., Guari, Y., Bettache, N., Larionova, J., Gary-Bobo, M.
- ID
- ZDB-PUB-220215-17
- Date
- 2021
- Source
- Journal of materials chemistry. B 9: 9670-9683 (Journal)
- Registered Authors
- Cubedo, Nicolas, Rossel, Mireille
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemical synthesis
- Antineoplastic Agents/radiation effects
- Antineoplastic Agents/therapeutic use*
- Cell Line, Tumor
- Ferrocyanides/chemistry
- Ferrocyanides/radiation effects
- Ferrocyanides/therapeutic use*
- Humans
- Iron/chemistry
- Iron/radiation effects
- Manganese/chemistry*
- Manganese/radiation effects
- Nanoparticles/chemistry
- Nanoparticles/radiation effects
- Nanoparticles/therapeutic use*
- Photochemical Processes
- Photothermal Therapy
- Triple Negative Breast Neoplasms/drug therapy*
- Xenograft Model Antitumor Assays
- Zebrafish
- PubMed
- 34726228 Full text @ J Mater Chem B
Citation
Cahu, M., Ali, L.M.A., Sene, S., Long, J., Camerel, F., Ciancone, M., Salles, F., Chopineau, J., Devoisselle, J.M., Felix, G., Cubedo, N., Rossel, M., Guari, Y., Bettache, N., Larionova, J., Gary-Bobo, M. (2021) A rational study of the influence of Mn2+-insertion in Prussian blue nanoparticles on their photothermal properties. Journal of materials chemistry. B. 9:9670-9683.
Abstract
We investigated a series of Mn2+-Prussian blue (PB) nanoparticles NazMnxFe1-x[Fe(CN)6]1-y□y·nH2O of similar size, surface state and cubic morphology with various amounts of Mn2+ synthesized through a one step self-assembly reaction. We demonstrated by a combined experimental-theoretical approach that during the synthesis, Mn2+ substituted Fe3+ up to a Mn/Na-Mn-Fe ratio of 32 at% in the PB structure, while for higher amounts, the Mn2[Fe(CN)6] analogue is obtained. For comparison, the post-synthetic insertion of Mn2+ in PB nanoparticles was also investigated and completed with Monte-Carlo simulations to probe the plausible adsorption sites. The photothermal conversion efficiency (η) of selected samples was determined and showed a clear dependence on the Mn2+amount with a maximum efficiency for a Mn/Na-Mn-Fe ratio of 10 at% associated with a dependence on the nanoparticle concentration. Evaluation of the in vitro photothermal properties of these nanoparticles performed on triple negative human breast adenocarcinoma (MDA-MB-231) cells by using continuous and pulsed laser irradiation confirm their excellent PTT efficiency permitting low dose use.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping