PUBLICATION

Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish

Authors
Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., Jin, M.
ID
ZDB-PUB-220115-6
Date
2022
Source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   147: 112629 (Journal)
Registered Authors
Keywords
Autophagy, MPTP, Natural products, Oxidative stress, Zebrafish, α-synuclein
MeSH Terms
  • Parkinson Disease/drug therapy*
  • Peptides/chemistry
  • Peptides/pharmacology*
  • Peptides/therapeutic use
  • Disease Models, Animal
  • Autophagy/drug effects
  • Zebrafish
  • Neuroprotective Agents/chemistry
  • Neuroprotective Agents/pharmacology*
  • Neuroprotective Agents/therapeutic use
  • Animals
  • Oxidative Stress/drug effects
(all 12)
PubMed
35030435 Full text @ Biomed. Pharmacother.
Abstract
Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN) and aggregation of α-synuclein (α-syn). Current PD therapies merely provide symptomatic relief, lacking the disease-modifying therapeutic strategies against that could reverse the ongoing neurodegeneration. In the quest of exploring novel disease modifying therapeutic strategies, compounds from natural sources have gained much attention in recent days. YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg) peptide is a multi-functional peptide isolated and purified from the visceral mass extract of Neptunea arthritica cumingii (NAC) with plethora of pharmacological activities, however its neuroprotective effect against MPTP induced PD model is not yet reported. We found YIAEDAER peptide co-treatment could suppressed the MPTP-induced locomotor impairment in zebrafish, ameliorates the MPTP induced degeneration of DA neurons, inhibited the loss of vasculature and loss of cerebral vessels, suppressed α-syn levels. Moreover, YIAEDAER peptide modulates several genes related to autophagy (α-syn, pink1, parkin, atg5, atg7, beclin1, ulk1b, ulk2, and ambra1a), and oxidative stress (sod1, sod2, gss, gpx4a, gsto2, and cat). Hence, our finding suggests that YIAEDAER peptide might be a potential therapeutic candidate against MPTP-induced PD like condition.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
pku2EtTransgenic Insertion
    y1TgTransgenic Insertion
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      No data available
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      Marker Marker Type Name
      EGFPEFGEGFP
      GFPEFGGFP
      1 - 2 of 2
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      Mapping
      No data available
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      Citation
      Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., Jin, M. (2022) Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 147:112629.