PUBLICATION
Dynamics of muscle growth and regeneration: Lessons from the teleost
- Authors
- Manneken, J.D., Dauer, M.V.P., Currie, P.D.
- ID
- ZDB-PUB-211230-41
- Date
- 2021
- Source
- Experimental cell research 411(2): 112991 (Review)
- Registered Authors
- Currie, Peter D., Dauer, Mervyn, Manneken, Jessica
- Keywords
- Muscle development, Muscle regeneration, Muscle stem cells, Satellite cells, Zebrafish
- MeSH Terms
-
- Animals
- Homeodomain Proteins/genetics
- Homeodomain Proteins/metabolism
- Macrophages/physiology
- Models, Biological
- Muscle Development/genetics
- Muscle Development/physiology*
- Muscle, Skeletal/cytology
- Muscle, Skeletal/growth & development
- Muscle, Skeletal/physiology
- Myoblasts, Skeletal/cytology
- Myoblasts, Skeletal/metabolism
- PAX2 Transcription Factor/genetics
- PAX2 Transcription Factor/metabolism
- PAX3 Transcription Factor/genetics
- PAX3 Transcription Factor/metabolism
- Regeneration/genetics
- Regeneration/physiology*
- Zebrafish/genetics
- Zebrafish/growth & development*
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 34958765 Full text @ Exp. Cell Res.
Citation
Manneken, J.D., Dauer, M.V.P., Currie, P.D. (2021) Dynamics of muscle growth and regeneration: Lessons from the teleost. Experimental cell research. 411(2):112991.
Abstract
The processes of myogenesis during both development and regeneration share a number of similarities across both amniotes and teleosts. In amniotes, the process of muscle formation is considered largely biphasic, with developmental myogenesis occurring through hyperplastic fibre deposition and postnatal muscle growth driven through hypertrophy of existing fibres. In contrast, teleosts continue generating new muscle fibres during adult myogenesis through a process of eternal hyperplasia using a dedicated stem cell system termed the external cell layer. During developmental and regenerative myogenesis alike, muscle progenitors interact with their niche to receive cues guiding their transition into myoblasts and ultimately mature myofibres. During development, muscle precursors receive input from neighbouring embryological tissues; however, during repair, this role is fulfilled by other injury resident cell types, such as those of the innate immune response. Recent work has focused on the role of macrophages as a pro-regenerative cell type which provides input to muscle satellite cells during regenerative myogenesis. As zebrafish harbour a satellite cell system analogous to that of mammals, the processes of regeneration can be interrogated in vivo with the imaging intensive approaches afforded in the zebrafish system. This review discusses the strengths of zebrafish with a focus on both the similarities and differences to amniote myogenesis during both development and repair.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping