PUBLICATION
Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development
- Authors
- Dawes, J.H.P., Kelsh, R.N.
- ID
- ZDB-PUB-211230-22
- Date
- 2021
- Source
- International Journal of Molecular Sciences 22(24): (Review)
- Registered Authors
- Kelsh, Robert
- Keywords
- Schwann cell, commitment, differentiation, dorsal root ganglion, fate specification, glia, neural crest cells, peripheral nervous system, sensory neuron, sympathetic neuron
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology
- Gene Expression Regulation, Developmental/physiology
- Neural Crest/physiology*
- Neurogenesis/physiology*
- Zebrafish/physiology
- PubMed
- 34948326 Full text @ Int. J. Mol. Sci.
Citation
Dawes, J.H.P., Kelsh, R.N. (2021) Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development. International Journal of Molecular Sciences. 22(24):.
Abstract
The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. The question of how this process is controlled has been the subject of an ongoing debate for more than 35 years. Based upon new observations of zebrafish pigment cell development, we have recently proposed a novel, dynamic model that we believe goes some way to resolving the controversy. Here, we will firstly summarize the traditional models and the conflicts between them, before outlining our novel model. We will also examine our recent dynamic modelling studies, looking at how these reveal behaviors compatible with the biology proposed. We will then outline some of the implications of our model, looking at how it might modify our views of the processes of fate specification, differentiation, and commitment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping