PUBLICATION
A bifunctional probe reveals increased viscosity and hydrogen sulfide in zebra fish model of Parkinson's disease
- Authors
- Shen, W., Wang, P., Xie, Z., Zhou, H., Hu, Y., Fu, M., Zhu, Q.
- ID
- ZDB-PUB-210810-2
- Date
- 2021
- Source
- Talanta 234: 122621 (Journal)
- Registered Authors
- Keywords
- Fluorescent probe, Hydrogen sulfide, Inflammation, Parkinson's disease, Viscosity
- MeSH Terms
-
- Animals
- Fluorescent Dyes
- HeLa Cells
- Humans
- Hydrogen Sulfide*
- Parkinson Disease*
- Viscosity
- Zebrafish
- PubMed
- 34364430 Full text @ Talanta
Citation
Shen, W., Wang, P., Xie, Z., Zhou, H., Hu, Y., Fu, M., Zhu, Q. (2021) A bifunctional probe reveals increased viscosity and hydrogen sulfide in zebra fish model of Parkinson's disease. Talanta. 234:122621.
Abstract
Altered H2S levels and intracellular viscosity have both been seen in Parkinson's disease (PD). However, how H2S and intracellular viscosity are involved in PD pathogenesis remains unknown. Herein, a dual-function fluorescent probe DF was designed and synthesized to analyze intracellular viscosity and hydrogen sulfide. It is a near-infrared fluorescence probe with improved photostability and large Stokes shift (110 nm). The probe reveals increased viscosity and hydrogen sulfide in zebrafish model of PD for the first time.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping