PUBLICATION
Sensitivity of Olfactory Sensory Neurons to food cues is tuned to nutritional states by Neuropeptide Y signalling
- Authors
- Kaniganti, T., Deogade, A., Maduskar, A., Mukherjee, A., Guru, A., Subhedar, N., Ghose, A.
- ID
- ZDB-PUB-210807-20
- Date
- 2021
- Source
- Journal of neurochemistry 159(6): 1028-1044 (Journal)
- Registered Authors
- Ghose, Aurnab, Kaniganti, Tarun, Maduskar, Aditi
- Keywords
- Neuropeptide Y, Olfactory Sensory Neurons, Olfactory sensitivity, neuromodulation, nutritional state
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cues*
- Eating/physiology*
- Female
- Humans
- Male
- Neuropeptide Y/analysis
- Neuropeptide Y/biosynthesis*
- Nutritional Status/physiology*
- Olfactory Mucosa/chemistry
- Olfactory Mucosa/metabolism*
- Olfactory Receptor Neurons/chemistry
- Olfactory Receptor Neurons/metabolism*
- Zebrafish
- PubMed
- 34359098 Full text @ J. Neurochem.
Citation
Kaniganti, T., Deogade, A., Maduskar, A., Mukherjee, A., Guru, A., Subhedar, N., Ghose, A. (2021) Sensitivity of Olfactory Sensory Neurons to food cues is tuned to nutritional states by Neuropeptide Y signalling. Journal of neurochemistry. 159(6):1028-1044.
Abstract
Modulation of sensory perception by homeostatic feedback from physiological states is central to innate purposive behaviours. Olfaction is an important predictive modality for feeding-related behaviours and its modulation has been associated with hunger-satiety states. However, the mechanisms mapping internal states to chemosensory processing in order to modify behaviour are poorly understood. In the zebrafish olfactory epithelium, a subset of olfactory sensory neurons (OSNs) and the terminal nerve projections express neuropeptide Y (NPY). Using a combination of neuronal activity and behavioral evaluation we find that NPY signalling in the peripheral olfactory system of zebrafish is correlated with its nutritional state and is both necessary and sufficient for the olfactory perception of food related odorants. NPY activity dynamically modulates the microvillar OSN activation thresholds and acts cooperatively with amino acid signalling resulting in a switch-like increase in OSN sensitivity in starved animals. We suggest that cooperative activation of phospholipase C by convergent signalling from NPY and amino acid receptors is central to this heightened sensitivity. This study provides ethologically relevant, physiological evidence for NPY signalling in the modulation of OSN sensitivity to food-associated amino acid cues. We demonstrate sensory gating directly at the level of OSNs and identify a novel mechanistic framework for tuning olfactory sensitivity to prevailing energy states.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping