PUBLICATION
Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations
- Authors
- Lengyel, I.M., Soroldoni, D., Oates, A.C., Morelli, L.G.
- ID
- ZDB-PUB-210717-2
- Date
- 2014
- Source
- Papers in physics 6: (Journal)
- Registered Authors
- Oates, Andrew
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 34267827 Full text @ Pap Phys
Citation
Lengyel, I.M., Soroldoni, D., Oates, A.C., Morelli, L.G. (2014) Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations. Papers in physics. 6:.
Abstract
We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the number of bound repressors affects transcription rate. Effective Hill exponents of the resulting regulatory functions reveal an increase in the nonlinearity of the feedback with the number of binding sites. We identify optimal configurations that maximize the nonlinearity of the feedback. We use a generic model of a biochemical oscillator to show that this increased nonlinearity is reflected in enhanced oscillations, with larger amplitudes over wider oscillatory ranges. Although the study is motivated by genetic oscillations in the zebrafish segmentation clock, our findings may reveal a general principle for gene regulation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping