PUBLICATION
A new insight into the lens: cytosolic PLAAT phospholipases degrade organelles to make the lens transparent
- Authors
- Morishita, H., Eguchi, T., Mizushima, N.
- ID
- ZDB-PUB-210709-2
- Date
- 2021
- Source
- Autophagy 17(9): 2645-2647 (Journal)
- Registered Authors
- Mizushima, Noboru, Morishita, Hideaki
- Keywords
- Autophagy, HRASLS, PLA2G16, PLAAT, lens, mice, organelle degradation, phospholipase, zebrafish
- MeSH Terms
-
- Autophagy
- Cytosol
- Lens, Crystalline*/metabolism
- Organelles/metabolism
- Phospholipases*/metabolism
- PubMed
- 34233574 Full text @ Autophagy
Citation
Morishita, H., Eguchi, T., Mizushima, N. (2021) A new insight into the lens: cytosolic PLAAT phospholipases degrade organelles to make the lens transparent. Autophagy. 17(9):2645-2647.
Abstract
All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping