PUBLICATION
Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment
- Authors
- Dos Santos, B.E., Giacomini, A.C.V.V., Marcon, L., Demin, K.A., Strekalova, T., de Abreu, M.S., Kalueff, A.V.
- ID
- ZDB-PUB-210601-21
- Date
- 2021
- Source
- Neuroscience letters 759: 135993 (Journal)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- anxiety-like behavior, locomotion, scopolamine, sex differences, temperament, zebrafish
- MeSH Terms
-
- Animals
- Anxiety/chemically induced*
- Behavior, Animal/drug effects
- Cholinergic Antagonists/toxicity*
- Female
- Locomotion/drug effects
- Male
- Scopolamine/toxicity*
- Sex Characteristics*
- Zebrafish
- PubMed
- 34058290 Full text @ Neurosci. Lett.
Citation
Dos Santos, B.E., Giacomini, A.C.V.V., Marcon, L., Demin, K.A., Strekalova, T., de Abreu, M.S., Kalueff, A.V. (2021) Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment. Neuroscience letters. 759:135993.
Abstract
Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-µM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying both individual and sex differences in behavioral and pharmacological responses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping