PUBLICATION
Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines
- Authors
- Roy, S.
- ID
- ZDB-PUB-210418-2
- Date
- 2021
- Source
- Trends in genetics : TIG 37(7): 612-615 (Other)
- Registered Authors
- Keywords
- Reissner fiber, UTS2R, Urotensin signaling, adolescent idiopathic scoliosis, cerebrospinal fluid, cilia
- MeSH Terms
-
- Adolescent
- Animals
- Cilia/genetics*
- Cilia/pathology
- Disease Models, Animal
- Humans
- Morphogenesis/genetics*
- Mutation/genetics
- Scoliosis/cerebrospinal fluid
- Scoliosis/genetics*
- Scoliosis/pathology
- Signal Transduction/genetics
- Spine/pathology
- Urotensins/cerebrospinal fluid
- Urotensins/genetics*
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 33858671 Full text @ Trends Genet.
Citation
Roy, S. (2021) Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines. Trends in genetics : TIG. 37(7):612-615.
Abstract
Adolescent idiopathic scoliosis (AIS) is a common skeletal disorder, characterized by abnormal spine curvatures. In zebrafish, cilia-driven cerebrospinal fluid flow and urotensin II pathway activity are required for proper spine morphogenesis. Genetic studies with AIS patients now establish a conservation of the zebrafish findings in the etiology of the disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping