PUBLICATION
Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish
- Authors
- Giacomini, A.C.V.V., Scolari, N., Marcon, L., Bueno, B.W., Dos Santos, B.E., Demin, K.A., Kalueff, A.V., de Abreu, M.S.
- ID
- ZDB-PUB-210411-5
- Date
- 2021
- Source
- Behavioural brain research 409: 113293 (Journal)
- Registered Authors
- Keywords
- acetaminophen, anxiety, behavior, cortisol, stress, zebrafish
- MeSH Terms
-
- Acetaminophen/pharmacology*
- Animals
- Anti-Anxiety Agents/pharmacology*
- Anxiety/drug therapy*
- Anxiety/etiology
- Behavior, Animal/drug effects*
- Disease Models, Animal
- Stress, Psychological/complications*
- Zebrafish
- PubMed
- 33838148 Full text @ Behav. Brain Res.
Citation
Giacomini, A.C.V.V., Scolari, N., Marcon, L., Bueno, B.W., Dos Santos, B.E., Demin, K.A., Kalueff, A.V., de Abreu, M.S. (2021) Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish. Behavioural brain research. 409:113293.
Abstract
Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most commonly used drugs globally. However, its CNS effects, especially on anxiety in clinical and animal studies, remain poorly understood. Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure. Overall, we report an anxiolytic-like profile of acute paracetamol, and its alleviation of stress-evoked anxiety, in adult short-fin wild type zebrafish. Collectively, these findings suggest complex neuroactive effects of paracetamol, and reinforce the growing importance of zebrafish models for drug screening, including the search for novel anti-stress therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping