PUBLICATION
Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods
- Authors
- Vigouroux, R.J., Duroure, K., Vougny, J., Albadri, S., Kozulin, P., Herrera, E., Nguyen-Ba-Charvet, K., Braasch, I., Suárez, R., Del Bene, F., Chédotal, A.
- ID
- ZDB-PUB-210410-3
- Date
- 2021
- Source
- Science (New York, N.Y.) 372: 150-156 (Journal)
- Registered Authors
- Braasch, Ingo, Del Bene, Filippo
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution*
- Brain/anatomy & histology*
- Cell Differentiation
- Eye/anatomy & histology
- Fish Proteins/genetics
- Fish Proteins/metabolism
- Fishes/anatomy & histology*
- Fishes/genetics*
- Fishes/metabolism
- Functional Laterality
- Humans
- Nuclear Proteins/genetics
- Nuclear Proteins/metabolism
- Retina/embryology
- Retina/metabolism
- Retinal Ganglion Cells/cytology*
- Transcription Factors/genetics
- Transcription Factors/metabolism
- Vision, Binocular
- Visual Pathways*
- Zebrafish/anatomy & histology
- Zebrafish/genetics
- PubMed
- 33833117 Full text @ Science
Citation
Vigouroux, R.J., Duroure, K., Vougny, J., Albadri, S., Kozulin, P., Herrera, E., Nguyen-Ba-Charvet, K., Braasch, I., Suárez, R., Del Bene, F., Chédotal, A. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods. Science (New York, N.Y.). 372:150-156.
Abstract
In most vertebrates, camera-style eyes contain retinal ganglion cell neurons that project to visual centers on both sides of the brain. However, in fish, ganglion cells were thought to innervate only the contralateral side, suggesting that bilateral visual projections appeared in tetrapods. Here we show that bilateral visual projections exist in non-teleost fishes and that the appearance of ipsilateral projections does not correlate with terrestrial transition or predatory behavior. We also report that the developmental program that specifies visual system laterality differs between fishes and mammals, as the Zic2 transcription factor, which specifies ipsilateral retinal ganglion cells in tetrapods, appears to be absent from fish ganglion cells. However, overexpression of human ZIC2 induces ipsilateral visual projections in zebrafish. Therefore, the existence of bilateral visual projections likely preceded the emergence of binocular vision in tetrapods.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping