PUBLICATION
Zebrafish as the toxicant screening model: Transgenic and omics approaches
- Authors
- Lai, K.P., Gong, Z., Tse, W.K.F.
- ID
- ZDB-PUB-210407-60
- Date
- 2021
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 234: 105813 (Review)
- Registered Authors
- Gong, Zhiyuan, Tse, Ka Fai William
- Keywords
- Endocrine disrupting chemicals, Omics, Transgenic model, Zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified/metabolism
- Ecosystem
- Endocrine Disruptors/toxicity
- Epigenomics*
- Metabolomics*
- Models, Animal
- Proteomics*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/growth & development
- Zebrafish/metabolism*
- PubMed
- 33812311 Full text @ Aquat. Toxicol.
Citation
Lai, K.P., Gong, Z., Tse, W.K.F. (2021) Zebrafish as the toxicant screening model: Transgenic and omics approaches. Aquatic toxicology (Amsterdam, Netherlands). 234:105813.
Abstract
The production of large amounts of synthetic industrial and biomedical compounds, together with environmental pollutants, poses a risk to our ecosystem and induces negative effects on the health of wildlife and human beings. With the emergence of the global problem of chemical contamination, the adverse biological effects of these chemicals are gaining attention among the scientific communities, industry, governments, and the public. Among these chemicals, endocrine disrupting chemicals (EDCs) are regarded as one of the major global issues that potentially affecting our health. There is an urgent need of understanding the potential hazards of such chemicals. Zebrafish have been widely used in the aquatic toxicology. In this review, we first discuss the strategy of transgenic lines that used in the toxicological studies, followed by summarizing the current omics approaches (transcriptomics, proteomics, metabolomics, and epigenomics) on toxicities of EDCs in this model. We will also discuss the possible transgenerational effects in zebrafish and future prospective of the integrated omics approaches with customized transgenic organism. To conclude, we summarize the current findings in the field, and provide our opinions on future environmental toxicity research in the zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping