PUBLICATION
Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae
- Authors
- Tan, M.T.H., Li, Y., Eshaghi Gorji, M., Gong, Z., Li, D.
- ID
- ZDB-PUB-210407-14
- Date
- 2021
- Source
- Viruses 13(3): (Journal)
- Registered Authors
- Gong, Zhiyuan
- Keywords
- 2′-fucosyllactose, antiviral, fucoidan, norovirus
- MeSH Terms
-
- Animals
- Antiviral Agents/pharmacology*
- Humans
- Larva/virology
- Norovirus/drug effects
- Norovirus/growth & development*
- Polysaccharides/pharmacology*
- Saliva/virology
- Trisaccharides/pharmacology*
- Virus Attachment/drug effects
- Virus Replication/drug effects
- Zebrafish/embryology
- Zebrafish/virology*
- PubMed
- 33799811 Full text @ Viruses
Citation
Tan, M.T.H., Li, Y., Eshaghi Gorji, M., Gong, Z., Li, D. (2021) Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae. Viruses. 13(3):.
Abstract
Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae Fucus vesiculosus) and 2'-Fucosyllactose (2'-FL). As a result, although both fucoidan and 2'-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2'-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping