ZFIN ID: ZDB-PUB-210319-24
The cell biology of inflammation: From common traits to remarkable immunological adaptations
Weavers, H., Martin, P.
Date: 2020
Source: The Journal of cell biology   219(7): (Review)
Registered Authors: Martin, Paul
Keywords: none
MeSH Terms:
  • Adaptation, Physiological/immunology*
  • Alarmins/immunology
  • Animals
  • Drosophila melanogaster/immunology
  • Drosophila melanogaster/microbiology
  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immunity, Innate*
  • Inflammation/history
  • Macrophages/immunology*
  • Macrophages/microbiology
  • Monocytes/immunology
  • Monocytes/microbiology
  • Neutrophils/immunology*
  • Neutrophils/microbiology
  • Pathogen-Associated Molecular Pattern Molecules/immunology
  • Phagocytosis
  • Wound Healing/immunology*
  • Wounds, Penetrating/immunology*
  • Wounds, Penetrating/microbiology
  • Zebrafish/immunology
  • Zebrafish/microbiology
PubMed: 32539109 Full text @ J. Cell Biol.
Tissue damage triggers a rapid and robust inflammatory response in order to clear and repair a wound. Remarkably, many of the cell biology features that underlie the ability of leukocytes to home in to sites of injury and to fight infection-most of which are topics of intensive current research-were originally observed in various weird and wonderful translucent organisms over a century ago by Elie Metchnikoff, the "father of innate immunity," who is credited with discovering phagocytes in 1882. In this review, we use Metchnikoff's seminal lectures as a starting point to discuss the tremendous variety of cell biology features that underpin the function of these multitasking immune cells. Some of these are shared by other cell types (including aspects of motility, membrane trafficking, cell division, and death), but others are more unique features of innate immune cells, enabling them to fulfill their specialized functions, such as encapsulation of invading pathogens, cell-cell fusion in response to foreign bodies, and their self-sacrifice as occurs during NETosis.