PUBLICATION
Regulation of Zebrafish Gonadal Sex Differentiation
- Authors
- Pradhan, A., Olsson, P.
- ID
- ZDB-PUB-210311-11
- Date
- 2016
- Source
- AIMS Molecular Science 3: 567-584 (Review)
- Registered Authors
- Pradhan, Ajay
- Keywords
- NFκB, prostaglandin, retinoic acid, gonads, primordial germ cell, gene regulation, sex chromosome
- MeSH Terms
- none
- PubMed
- none Full text @ AIMS Mol. Sci.
Citation
Pradhan, A., Olsson, P. (2016) Regulation of Zebrafish Gonadal Sex Differentiation. AIMS Molecular Science. 3:567-584.
Abstract
While the master regulator gene Sry on the mammalian Y chromosome controls the switch for initiating male sex differentiation, many other species rely on environmental factors for gonadal sex differentiation. Yet other species, like zebrafish, appears to rely on a multitude of genetic cues for gonadal sex differentiation. Zebrafish gonadal differentiation initiates with the onset of a juvenile ovary stage and depending on the influence of unknown genetic factors either maintains oocyte development or initiate apoptotic processes to override the female differentiation pathway. In this review, we explore the role of different factors and genes that have been reported to influence zebrafish gonadal sex differentiation. We also give a brief insight of primordial germ cell (PGC) involvement in shaping male and female signaling pathway in gonadal development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping