PUBLICATION
Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
- Authors
- Ka, J., Jin, S.W.
- ID
- ZDB-PUB-210205-8
- Date
- 2021
- Source
- Journal of lipid and atherosclerosis 10: 42-56 (Review)
- Registered Authors
- Jin, Suk-Won
- Keywords
- Atherosclerosis, Dyslipidemia, Lipid metabolism, Zebrafish
- MeSH Terms
- none
- PubMed
- 33537252 Full text @ J Lipid Atheroscler
Citation
Ka, J., Jin, S.W. (2021) Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases. Journal of lipid and atherosclerosis. 10:42-56.
Abstract
Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated over decades, we still lack comprehensive understanding on the etiology of dyslipidemia due to the complexity and the innate multimodality of the diseases. While mouse has been the model organism of choice to investigate the pathophysiology of human dyslipidemia, zebrafish, a small freshwater fish which has traditionally used to study vertebrate development, has recently emerged as an alternative model organism. In this review, we will provide comprehensive perspective on zebrafish as a model organism for human dyslipidemia; we will discuss the attributes of zebrafish as a model, and compare the lipid metabolism in zebrafish and humans. In addition, we will summarize current landscape of zebrafish-based dyslipidemia research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping