|ZFIN ID: ZDB-PUB-210205-8|
Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
Ka, J., Jin, S.W.
|Source:||Journal of lipid and atherosclerosis 10: 42-56 (Review)|
|Registered Authors:||Jin, Suk-Won|
|Keywords:||Atherosclerosis, Dyslipidemia, Lipid metabolism, Zebrafish|
|PubMed:||33537252 Full text @ J Lipid Atheroscler|
Ka, J., Jin, S.W. (2021) Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases. Journal of lipid and atherosclerosis. 10:42-56.
ABSTRACTDyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated over decades, we still lack comprehensive understanding on the etiology of dyslipidemia due to the complexity and the innate multimodality of the diseases. While mouse has been the model organism of choice to investigate the pathophysiology of human dyslipidemia, zebrafish, a small freshwater fish which has traditionally used to study vertebrate development, has recently emerged as an alternative model organism. In this review, we will provide comprehensive perspective on zebrafish as a model organism for human dyslipidemia; we will discuss the attributes of zebrafish as a model, and compare the lipid metabolism in zebrafish and humans. In addition, we will summarize current landscape of zebrafish-based dyslipidemia research.
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