PUBLICATION
miRNAs and Müller Glia Reprogramming During Retina Regeneration
- Authors
- Konar, G.J., Ferguson, C., Flickinger, Z., Kent, M.R., Patton, J.G.
- ID
- ZDB-PUB-210205-10
- Date
- 2021
- Source
- Frontiers in cell and developmental biology 8: 632632 (Review)
- Registered Authors
- Patton, James G.
- Keywords
- Müller glia, miRNA, regeneration, retina, zebrafish
- MeSH Terms
- none
- PubMed
- 33537319 Full text @ Front Cell Dev Biol
Citation
Konar, G.J., Ferguson, C., Flickinger, Z., Kent, M.R., Patton, J.G. (2021) miRNAs and Müller Glia Reprogramming During Retina Regeneration. Frontiers in cell and developmental biology. 8:632632.
Abstract
The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of key factors, altered chromatin accessibility, or inhibition of kinase/signaling cascades, a clearer picture of the key regulatory events that control retina regeneration is emerging. In all cases, Müller glia (MG) serve as an adult retinal stem cell that must be reprogrammed to allow for regeneration, with the end goal being to understand why regenerative pathways are blocked in mammals, but spontaneous in other vertebrates such as zebrafish. miRNAs have emerged as key gene regulatory molecules that control both development and regeneration in vertebrates. Here, we focus on a small subset of miRNAs that control MG reprogramming during retina regeneration and have the potential to serve as therapeutic targets for treatment of visual disorders and damage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping