PUBLICATION
No air without autophagy: autophagy is important for lung and swim bladder inflation
- Authors
- Morishita, H., Kanda, Y., Mizushima, N.
- ID
- ZDB-PUB-210204-2
- Date
- 2021
- Source
- Autophagy 17(4): 1040-1041 (Other)
- Registered Authors
- Mizushima, Noboru
- Keywords
- autophagy, lamellar body, lung, lysosome-related organelle, swim bladder, zebrafish
- MeSH Terms
-
- Animals
- Autophagy
- Lung
- Mice
- Surface-Active Agents*
- Urinary Bladder
- Zebrafish*
- PubMed
- 33530832 Full text @ Autophagy
Citation
Morishita, H., Kanda, Y., Mizushima, N. (2021) No air without autophagy: autophagy is important for lung and swim bladder inflation. Autophagy. 17(4):1040-1041.
Abstract
Macroautophagy is a catabolic process critical for the degradation of intracellular material, but its physiological functions in vertebrates are not fully understood. Here, we discuss our recent finding that macroautophagy plays a role in lamellar body maturation. The lamellar body is a lysosome-related organelle and stores phospholipid-containing surfactant complexes that reduce the surface tension of the air-water interface in order to inflate the airspace in lungs and swim bladders. In the epithelial cells of these organs, autophagosomes fuse with immature lamellar bodies to increase their size and lipid contents. This function is essential for respiration after birth in mice and for maintaining buoyancy in zebrafish. These findings unveil a novel function of macroautophagy in the maturation of surfactant-containing lamellar bodies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping