PUBLICATION

To be or not to be: endothelial cell plasticity in development, repair, and disease

Authors
Greenspan, L.J., Weinstein, B.M.
ID
ZDB-PUB-210116-8
Date
2021
Source
Angiogenesis   24(2): 251-269 (Review)
Registered Authors
Greenspan, Leah, Weinstein, Brant M.
Keywords
Endothelial cell, Transdifferentiation, Vascular plasticity, Zebrafish
MeSH Terms
  • Animals
  • Arteries/metabolism
  • Cell Differentiation*
  • Endothelial Cells/metabolism*
  • Hematopoietic Stem Cells
  • Humans
  • Lymphatic Vessels/metabolism
  • Neovascularization, Physiologic*
  • Veins/metabolism
  • Wounds and Injuries/metabolism*
  • Wounds and Injuries/therapy
  • Zebrafish/metabolism*
PubMed
33449300 Full text @ Angiogenesis
Abstract
Endothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and other cell types. Adult endothelial cells are some of the longest-lived cells in the body and their participation as stable components of the vascular wall is critical for the proper function of both the circulatory and lymphatic systems, yet these cells also display a remarkable capacity to undergo changes in their differentiated identity during injury, disease, and even normal physiological changes in the vasculature. Here, we discuss how endothelial cells become specified during development as arterial, venous, or lymphatic endothelial cells or convert into hematopoietic stem and progenitor cells or cardiac valve cells. We compare findings from in vitro and in vivo studies with a focus on the zebrafish as a valuable model for exploring the signaling pathways and environmental cues that drive these transitions. We also discuss how endothelial plasticity can aid in revascularization and repair of tissue after damage- but may have detrimental consequences under disease conditions. By better understanding endothelial plasticity and the mechanisms underlying endothelial fate transitions, we can begin to explore new therapeutic avenues.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes