ZFIN ID: ZDB-PUB-201203-7
Blood in the water: recent uses of zebrafish to study myeloid biology
Wattrus, S.J., Zon, L.I.
Date: 2021
Source: Current opinion in hematology   28: 43-49 (Review)
Registered Authors: Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Hematopoiesis
  • Humans
  • Infections/immunology
  • Infections/pathology*
  • Leukemia, Myeloid/immunology
  • Leukemia, Myeloid/pathology*
  • Myeloid Cells/immunology
  • Myeloid Cells/pathology*
  • Regeneration
  • Zebrafish*/embryology
  • Zebrafish*/physiology
PubMed: 33264224 Full text @ Curr. Opin. Hematol.
Myeloid cells contribute to immune response to infection and tissue regeneration after injury as well as to the developmental induction of the hematopoietic system overall. Here we review recent uses of zebrafish to advance the study of myeloid biology in development and disease.
Recent studies have made use of advanced imaging and genetic strategies and have highlighted key concepts in myeloid cell behavior. These include immune-cell cross-talk and subpopulation response in infection and regeneration, and tightly regulated inflammatory and tissue remodeling behaviors in development.
These new findings will shape our understanding of the developmental origins of immune populations as well as their specific cellular behaviors at all stages of infection, regeneration, and myeloid neoplasms.