ZFIN ID: ZDB-PUB-201120-80
Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies
Tsai, S.L., Nödl, M.T., Galloway, J.L.
Date: 2020
Source: Developmental dynamics : an official publication of the American Association of Anatomists   250(3): 393-413 (Review)
Registered Authors: Galloway, Jenna
Keywords: connective tissues, injury, repair, stem cells, tendon
MeSH Terms: none
PubMed: 33169466 Full text @ Dev. Dyn.
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ABSTRACT
Tendons are specialized matrix-rich connective tissues that transmit forces from muscle to bone and are essential for movement. As tissues that frequently transfer large mechanical loads, tendons are commonly injured in patients of all ages. Following injury, mammalian tendons heal poorly through a slow process that forms disorganized fibrotic scar tissue with inferior biomechanical function. Current treatments are limited and patients can be left with a weaker tendon that is likely to re-rupture and an increased chance of developing degenerative conditions. More effective, alternative treatments are needed. However, our current understanding of tendon biology remains limited. Here, we emphasize why expanding our knowledge of tendon development, healing, and regeneration is imperative for advancing tendon regenerative medicine. We provide a comprehensive review of the current mechanisms governing tendon development and healing and further highlight recent work in regenerative tendon models including the neonatal mouse and zebrafish. Importantly, we discuss how present and future discoveries can be applied to both augment current treatments and design novel strategies to treat tendon injuries. This article is protected by copyright. All rights reserved.
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