PUBLICATION
Crocins from Crocus sativus L. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish
- Authors
- Kakouri, E., Agalou, A., Kanakis, C., Beis, D., Tarantilis, P.A.
- ID
- ZDB-PUB-201120-108
- Date
- 2020
- Source
- Molecules 25(22): (Journal)
- Registered Authors
- Beis, Dimitris
- Keywords
- crocins, glucose, insulin, pck1, β-pancreatic cells
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Blood Glucose/metabolism
- Carotenoids/analysis
- Carotenoids/pharmacology*
- Crocus/chemistry*
- Gluconeogenesis
- Glucose/metabolism
- Hyperglycemia/drug therapy*
- Insulin/metabolism
- Insulin-Secreting Cells/metabolism
- Ions
- Pancreas/embryology
- Pancreas/metabolism
- Phosphoenolpyruvate Carboxykinase (GTP)/metabolism
- Plant Extracts/pharmacology
- Zebrafish
- PubMed
- 33182581 Full text @ Molecules
Citation
Kakouri, E., Agalou, A., Kanakis, C., Beis, D., Tarantilis, P.A. (2020) Crocins from Crocus sativus L. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish. Molecules. 25(22):.
Abstract
Diabetes mellitus is a disease characterized by persistent high blood glucose levels and accompanied by impaired metabolic pathways. In this study, we used zebrafish to investigate the effect of crocins isolated from Crocus sativus L., on the control of glucose levels and pancreatic β-cells. Embryos were exposed to an aqueous solution of crocins and whole embryo glucose levels were measured at 48 h post-treatment. We showed that the application of crocins reduces zebrafish embryo glucose levels and enhances insulin expression. We also examined whether crocins are implicated in the metabolic pathway of gluconeogenesis. We showed that following a single application of crocins and glucose level reduction, the expression of phosphoenolpyruvate carboxykinase1 (pck1), a key gene involved in glucose metabolism, is increased. We propose a putative role for the crocins in glucose metabolism and insulin management.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping