PUBLICATION
The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
- Authors
- Venturini, V., Pezzano, F., Català Castro, F., Häkkinen, H.M., Jiménez-Delgado, S., Colomer-Rosell, M., Marro, M., Tolosa-Ramon, Q., Paz-López, S., Valverde, M.A., Weghuber, J., Loza-Alvarez, P., Krieg, M., Wieser, S., Ruprecht, V.
- ID
- ZDB-PUB-201020-27
- Date
- 2020
- Source
- Science (New York, N.Y.) 370(6514): (Journal)
- Registered Authors
- Ruprecht, Verena
- Keywords
- none
- MeSH Terms
-
- Actomyosin/metabolism
- Animals
- Cell Movement
- Cell Shape*
- Lipase/metabolism
- Mechanotransduction, Cellular*
- Myosin Type II/metabolism
- Nuclear Envelope/physiology*
- Phospholipases A2, Cytosolic/metabolism*
- Zebrafish
- PubMed
- 33060331 Full text @ Science
Citation
Venturini, V., Pezzano, F., Català Castro, F., Häkkinen, H.M., Jiménez-Delgado, S., Colomer-Rosell, M., Marro, M., Tolosa-Ramon, Q., Paz-López, S., Valverde, M.A., Weghuber, J., Loza-Alvarez, P., Krieg, M., Wieser, S., Ruprecht, V. (2020) The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior. Science (New York, N.Y.). 370(6514):.
Abstract
The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway, controlling actomyosin contractility and migration plasticity. Our data support that the nucleus establishes a functional module for cellular proprioception that enables cells to sense shape variations for adapting cellular behavior to their microenvironment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping