PUBLICATION
Airinemes: thin cellular protrusions mediate long-distance signalling guided by macrophages
- Authors
- Eom, D.S.
- ID
- ZDB-PUB-200819-12
- Date
- 2020
- Source
- Open Biology 10: 200039 (Review)
- Registered Authors
- Eom, Dae Seok
- Keywords
- airinemes, cell–cell communication, cytonemes, filopodia, macrophage, zebrafish
- MeSH Terms
-
- Animals
- Biological Transport
- Cell Communication*
- Cell Shape
- Cell Surface Extensions/physiology*
- Cytoplasmic Vesicles/metabolism
- Humans
- Macrophages/physiology*
- Organ Specificity
- Signal Transduction*
- PubMed
- 32810422 Full text @ Open Biol.
Citation
Eom, D.S. (2020) Airinemes: thin cellular protrusions mediate long-distance signalling guided by macrophages. Open Biology. 10:200039.
Abstract
Understanding the mechanisms of cell-to-cell communication is one of the fundamental questions in biology and medicine. In particular, long-range signalling where cells communicate over several cell diameters is vital during development and homeostasis. The major morphogens, their receptors and intracellular signalling cascades have largely been identified; however, there is a gap in our knowledge of how such signalling factors are propagated over a long distance. In addition to the diffusion-based propagation model, new modalities of disseminating signalling molecules have been identified. It has been shown that cells can communicate with direct contact through long, thin cellular protrusions between signal sending and receiving cells at a distance. Recent studies have revealed a type of cellular protrusion termed 'airinemes' in zebrafish pigment cell types. They share similarities with previously reported cellular protrusions; however, they also exhibit distinct morphology and features. Airinemes are indispensable for pigment pattern development by mediating long-distance Delta-Notch signalling between different pigment cell types. Notably, airineme-mediated signalling is dependent on skin-resident macrophages. Key findings of airineme-mediated intercellular signalling in pattern development, their interplay with macrophages and their implications for the understanding of cellular protrusion-mediated intercellular communication will be discussed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping