PUBLICATION

Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model

Authors
Jaiswal, Y., Shaikh, M.F., Wang, I., Yong, Y., Lin Lin Lee, V., Williams, L.
ID
ZDB-PUB-200817-11
Date
2020
Source
Brain sciences   10(8): (Journal)
Registered Authors
Keywords
Kava (Piper methysticum), PTZ-induced seizure model, anti-convulsive activity, zebrafish
MeSH Terms
none
PubMed
32796575 Full text @ Brain Sci
Abstract
Kava roots have been extensively studied in clinical trials as potential candidate anti-anxiety drugs. However, anti-convulsive properties of various tissues of stems of Kava have not been reported to date. The objective of the study was to evaluate the anti-convulsive potential of aqueous extracts prepared from specific tissues of Kava (Piper methysticum) stems in zebrafish, using the PTZ-induced seizure model. The potency of each extract was compared in terms of the intensity of seizure scores and onset time after pre-treating the zebrafish before the PTZ challenge. The results indicate that aqueous extract of Kava stems without peel after 45 min of pre-treatment exhibited anti-convulsive potential at the dose of 50 mg/L. This study provides evidence to the anti-convulsive properties of peeled Kava stems and its potential for investigation and design of candidate anti-convulsive drugs.
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