PUBLICATION
Comparative genomic insights into Yersinia hibernica - a commonly misidentified Yersinia enterocolitica-like organism
- Authors
- Nguyen, S.V., Muthappa, D.M., Eshwar, A.K., Buckley, J.F., Murphy, B.P., Stephan, R., Lehner, A., Fanning, S.
- ID
- ZDB-PUB-200724-25
- Date
- 2020
- Source
- Microbial genomics 6(9): (Journal)
- Registered Authors
- Keywords
- Yersinia enterocolitica, Yersinia hibernica, comparative genomics, zebrafish embryo
- MeSH Terms
-
- Animals
- Conjugation, Genetic
- Diagnosis, Differential
- Disease Models, Animal
- Embryo, Nonmammalian/microbiology*
- Food Microbiology
- Genomics/methods*
- Phylogeny
- Swine
- Virulence Factors/genetics
- Yersinia/classification*
- Yersinia/genetics
- Yersinia/isolation & purification
- Yersinia/pathogenicity
- Yersinia Infections/diagnosis*
- Yersinia enterocolitica/classification*
- Yersinia enterocolitica/genetics
- Yersinia enterocolitica/isolation & purification
- Yersinia enterocolitica/pathogenicity
- Zebrafish
- PubMed
- 32701425 Full text @ Microb Genom
Citation
Nguyen, S.V., Muthappa, D.M., Eshwar, A.K., Buckley, J.F., Murphy, B.P., Stephan, R., Lehner, A., Fanning, S. (2020) Comparative genomic insights into Yersinia hibernica - a commonly misidentified Yersinia enterocolitica-like organism. Microbial genomics. 6(9):.
Abstract
Food-associated outbreaks linked to enteropathogenic Yersinia enterocolitica are of concern to public health. Pigs and their meat are recognized risk factors for transmission of Y. enterocolitica. This study aimed to describe the comparative genomics of Y. enterocolitica along with a number of misclassified Yersinia isolates, now constituting the recently described Yersinia hibernica. The latter was originally cultured from an environmental sample taken at a pig slaughterhouse. Unique features were identified in the genome of Y. hibernica, including a novel integrative conjugative element (ICE), denoted as ICEYh-1 contained within a 255 kbp region of plasticity. In addition, a zebrafish embryo infection model was adapted and applied to assess the virulence potential among Yersinia isolates including Y. hibernica.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping