PUBLICATION
Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio)
- Authors
- Messina, A., Boiti, A., Vallortigara, G.
- ID
- ZDB-PUB-200722-4
- Date
- 2020
- Source
- The European journal of neuroscience 53(2): 362-375 (Journal)
- Registered Authors
- Keywords
- Danio rerio, autism-related genes, brain asymmetry, developmental dyscalculia-related genes, telencephalic lateralization
- MeSH Terms
-
- Animals
- Cation Transport Proteins*
- Gene Expression Regulation, Developmental
- Intracellular Signaling Peptides and Proteins
- Mice
- Nerve Tissue Proteins/genetics
- Receptors, Immunologic
- Transcription Factors/genetics
- Zebrafish*
- Zebrafish Proteins/genetics
- PubMed
- 32692463 Full text @ Eur. J. Neurosci.
Citation
Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375.
Abstract
The left and right distribution of a set of twenty-six genes in the zebrafish pallium was examined by RT-qPCR experiments. The analysis comprised four general pallial markers (eomesa, emx2, emx3 and prox1); eight genes, dapper1, htr3a, htr3b, htr4, id2, ndr2 and pkcβ and lmo4, that have been described as asymmetric distributed in the brain of mammals (human and mouse); six genes, arrb2, auts2, baiap2, fez1, gap43 and robo1, asymmetrically distributed in the mammalian cortex, that have been associated with autism in humans; and, eight genes, baz1b, fzd9, limk1, tubgcp5, cyfip1, grik1a, nipa1 and nipa2, which have been associated with developmental dyscalculia, a brain disability linked to brain laterality in human. We found a leftward bias in the expression of 10 genes (dapper1, htr3a, htr3b, htr4, id2, ndr2, pkcß,auts2, baiap2 and grik1a), and a rightward bias for 8 genes (lmo4, arrb2, fez1, gap43, robo1) in agreement with the data reported in mammals. We also found a rightward lateralization for nipa1 and nipa2, whereas the remaining genes (eomesa, emx2, emx3, prox1, baz1b, cyfip1, fzd9, limk1 and tubgpc5) were bilaterally distributed. These findings suggest a basic homology in the asymmetric expression of several pallial vertebrate genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping