PUBLICATION
Preclinical methodological approaches investigating of the effects of alcohol on perinatal and adolescent neurodevelopment
- Authors
- Bailey, C.D.C., Gerlai, R., Cameron, N.M., Marcolin, M.L., McCormick, C.M.
- ID
- ZDB-PUB-200719-20
- Date
- 2020
- Source
- Neuroscience and biobehavioral reviews 116: 436-451 (Review)
- Registered Authors
- Gerlai, Robert T.
- Keywords
- alcohol, neurodevelopment, preclinical models, rodents, zebrafish
- MeSH Terms
-
- Alcohol Drinking
- Animals
- Ethanol*
- Zebrafish*
- PubMed
- 32681938 Full text @ Neurosci. Biobehav. Rev.
Citation
Bailey, C.D.C., Gerlai, R., Cameron, N.M., Marcolin, M.L., McCormick, C.M. (2020) Preclinical methodological approaches investigating of the effects of alcohol on perinatal and adolescent neurodevelopment. Neuroscience and biobehavioral reviews. 116:436-451.
Abstract
Despite much evidence of its economic and social costs, alcohol use continues to increase. Much remains to be known as to the effects of alcohol on neurodevelopment across the lifespan and in both sexes. We provide a comprehensive overview of the methodological approaches to ethanol administration when using animal models (primarily rodent models) and their translational relevance, as well as some of the advantages and disadvantages of each approach. Special consideration is given to early developmental periods (prenatal through adolescence), as well as to the types of research questions that are best addressed by specific methodologies. The zebrafish is used increasingly in alcohol research, and how to use this model effectively as a preclinical model is reviewed as well.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping