ZFIN ID: ZDB-PUB-200716-7
Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow
Taberner, L., Bañón, A., Alsina, B.
Date: 2020
Source: Cell Reports   32: 107903 (Journal)
Registered Authors: Alsina, Berta
Keywords: Dll4/Notch, blood flow, cytoneme, inner ear, neurogenesis, niche, sensory neurons, statoacoustic ganglion, vascular, zebrafish
MeSH Terms:
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors/metabolism
  • Blood Circulation/drug effects
  • Blood Circulation/physiology*
  • Blood Vessels/cytology*
  • Body Patterning/drug effects
  • Bridged Bicyclo Compounds, Heterocyclic/pharmacology
  • Cell Count
  • Cell Cycle*/drug effects
  • Cell Differentiation*/drug effects
  • Cell Proliferation/drug effects
  • Down-Regulation/drug effects
  • Endothelial Cells/drug effects
  • Endothelial Cells/metabolism
  • Intracellular Signaling Peptides and Proteins/metabolism
  • Nerve Tissue Proteins/metabolism
  • Neurogenesis/drug effects
  • Oxygen/metabolism
  • Pseudopodia/drug effects
  • Pseudopodia/metabolism
  • Receptors, Notch/metabolism
  • Sensory Receptor Cells/cytology*
  • Sensory Receptor Cells/drug effects
  • Sensory Receptor Cells/metabolism
  • Signal Transduction/drug effects
  • Skull/blood supply
  • Thiazolidines/pharmacology
  • Transcription, Genetic/drug effects
  • Vestibulocochlear Nerve/cytology
  • Vestibulocochlear Nerve/metabolism
  • Zebrafish
  • Zebrafish Proteins/metabolism
PubMed: 32668260 Full text @ Cell Rep.
ABSTRACT
In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in zebrafish are uncovered. The first involves precise spatiotemporal endothelial-neuroblast cytoneme contacts and Dll4-Notch signaling to restrain neuroblast proliferation. The second, instead, requires blood flow to trigger a transcriptional response that modifies neuroblast metabolic status and induces sensory neuron differentiation. In contrast, no role of sensory neurogenesis in vascular development is found, suggesting unidirectional signaling from vasculature to sensory neuroblasts. Altogether, we demonstrate that the cranial vasculature constitutes a niche component of the sensory ganglia that regulates the pace of their growth and differentiation dynamics.
ADDITIONAL INFORMATION