PUBLICATION

Studying the Pathophysiology of Parkinson's Disease Using Zebrafish

Authors
Barnhill, L.M., Murata, H., Bronstein, J.M.
ID
ZDB-PUB-200711-2
Date
2020
Source
Biomedicines   8(7): (Review)
Registered Authors
Barnhill, Lisa, Bronstein, Jeff
Keywords
Parkinson’s disease, dopaminergic neuron, toxins, zebrafish
MeSH Terms
none
PubMed
32645821 Full text @ Biomedicines
Citation
Barnhill, L.M., Murata, H., Bronstein, J.M. (2020) Studying the Pathophysiology of Parkinson's Disease Using Zebrafish. Biomedicines. 8(7):.
Abstract
Parkinson's disease is a common neurodegenerative disorder leading to severe disability. The clinical features reflect progressive neuronal loss, especially involving the dopaminergic system. The causes of Parkinson's disease are slowly being uncovered and include both genetic and environmental insults. Zebrafish have been a valuable tool in modeling various aspects of human disease. Here, we review studies utilizing zebrafish to investigate both genetic and toxin causes of Parkinson's disease. They have provided important insights into disease mechanisms and will be of great value in the search for disease-modifying therapies.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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